Liliana Marasco Garrido, President and Co-Founder of Litaff
         Shari Fiksdal, President & Co-Founder of International
                                                          Post Polio Support 

Three important issues came from the symposium, we feel it is important that we share this latest news with everyone.
Some may already know there is a WHO Code for Post Polio Syndrome, that there is
a possible marker waiting for approval by the ...Journal 
 And that they are continuing to find IV Gamma globulin is helping those
of us with PPS!  We apologize that this release has been delayed due to to ill health.




Dr. Brian Joseph, PhD. (Harvard) brought us up to date on IV Gamma Globulin Studies of
Dr. H. Gonzalez! Dr. Kristian Borg and Henrick Gonzalez in Sweden have been working for
many years testing the benefits of IV Gamma Globulin for PPS patients. 
Dr. Joseph asked Dr. Henrik Gonzalez about their test results since their last release in 2008. 
Dr. Joseph explained that the tests being done in Sweden by
Dr. Henrick Gonzalez and Dr.  Kristian Borg had proven to be successful
and their research into the cause of PPS was “revolutionary

1.   The study proved gamma helps PPS.
2.  The study shows we have fragments of polio protein in our spinal cords, which causes our immune systems to continue to battle the polio virus that was there.  This and not dying neurons is what is causing PPS by weakening our immune systems.  Our body is still in the fight mode to kill off the tiny polio fragments in our bodies.  This does not mean we still have polio,  just remnants of the old virus our immune systems are still attacking, causing further degeneration.
 3.  And even more importantly, they have found a blood test to tell if you have PPS!                                                                                                                                  
Dr. Brian Joseph 
The details will all be released as soon as the peer review process is complete.

Here is a letter from Dr. Henrik Gonzalez to Liliana Marasco Garrido of Litaff confirming the statements above!
From: Henrik Gonzalez
Date: 5 de agosto de 2010 14:34:29 CDT
 To: "Asociacion Postpolio Litaff A.C_ APPLAC" <litaffac@prodigy.net.mx>
 RE: Re: Dr. Henrik Gonzales Regards From México PPS Organization
 Very nice to hear from You Liliana.
 Brian and I have corresponded for some years.  For your information, we have two unpublished studies.

When studies are unpublished I am not able to tell you too much about the results, but:

 The first is the one year follow up of Xepol (IVIG) with very promising results and the other
 a method to diagnose PPS by a very simple blood test.
  Very warm regards
 You can read below that Grifols has already bought the rights to Xepol:                             

Mtra. RitaVelásquez Lerma,
Subdirectora de Registros de Salud y Discapacidad Del INEGI

Sin título1ppp-copia-1

World Health Code  for  PPS “G 14” for PPS:          

In 2009 and as a result of the annual meeting of the Committee on
Review and Update of the World Health Organization (WHO), which
took place in the Indian capital Delhi during the month of October 2008,
the International Classification Diseases, version 10 (ICD-10) has been awarded
specific location to Post-Polio Syndrome (PPS) classified under
the code "G14" and excluded from code B91 (Sequelae of poliomyelitis), which
considered it before this body covered. International Statistical Classification of
Diseases and Related Health Problems. "With these changes the codes are assigned by
the WHO as one can read:"

Classification of polio sequelae and late effects and secondary

(ICD-10, WHO) .                                 
                                                         G14 Postpolio 
                  Includes:  Post Polio  Syndrome   -  Excludes: Postpolio Sequelae

  Dr. Susanna Reyes Rodriguez presented the latest information on

Transfer Factor and IV Gamma studies in Mexico!


Dra. Rodriguez is already using Transfer Factor in Mexico and had just finished
her studies with PPS and IV gamma. 
Dra. Rodriguez said she had found gamma to be helpful in other
Central Nervous System illnesses
and was looking forward to furthering her studies with PPS. 
 She had one medical institution and  Dr. Carlos Vallbona  volunteer to help her work with these studies.
                                                      Warm regards to all,
        Sin títuloliliana             shai       
   Mrs.  Liliana Marasco Garrido                             Shari Fiksdal, President ; Co-Founder  
    Post Polio Association Litaff ,A.C_APPLAC                                         International Post Polio Support Org. 
          Sin título19                                                                               Sin título18
                                                        Mr. Ernesto Maury Ruiz
                                                    Vice President & Cofounder
Websites:  APPLAC http://www.postpoliolitaff.org  or http://www.mexicopostpolio.com
                        IPPSO http://www.ippso-world.org 
Email       APPLAC litaffac@prodigy.net.mx  
                        IPPSO Fiksdalpps@yahoo.com
                 Tel/Fax  : Litaff (52) 55742926     IPPSO  (01) 541-772-1102
 © ® To republishedthis this press release you must get permission from
Liliana  Marasco Garrido or Shari Fiksdal and it must be republished in
it's entirety if permission is received.
Prohibida su publicación, todos los derechos reservados, solicitar
permiso a Liliana Marasco Garrido Presidenta y Fundadora de
APPLAC o a Mrs Shari Fiksdal ©®
      STOCKHOLM, SWEDEN – 26 August, 2008 ‐
 Pharmalink AB today announces positive results from a follow‐on Phase III study of Xepol®,
its candidate for the treatment of post‐polio syndrome (PPS). The data have shown the candidate to be effective an
d well tolerated with no serious adverse events attributed to the product being reported in the treated patients.
The Phase III study, involving 142 patients, is a placebo controlled, double blind trial designed to evaluate the efficacy
and safety of Xepol® in PPS, a neurological pain and weakness syndrome in patients that have survived poliovirus infection.
The original placebo controlled, double blind Phase III trial was six months
(Gonzalez et al (2006) Lancet Neurology 5:493‐500)
and this follow‐ up period was another six months.
The follow‐on results strengthen the position of this novel treatment modality for PPS by demonstrating a reduction of
inflammatory  cytokines in the cerebrospinal fluid and a significant reduction of symptoms of PPS while also showing that Xepol®
is safe and well tolerated with few or no side‐effects. Endpoints studied were pain, walking ability and SF‐36 scores (a common self assessment scoring system that measures physical and psychological variables).
 All showed significant and clinically meaning fulresults. Full results are to be published in a peer review journal.
Xepol®, the first medical PPS treatment , is an injectable biologic product, administered once per 9‐12 months, which down
‐regulates the inflammatory process in the nervous system of PPS patients. The concept and medical hypothesis was first developed by Dr Henrik Gonzalez and Professor Kristian Borg, scientists at the Karolinska Institute (Sweden)
. Pharmalink licensed the invention and is now working to bring the candidate towards registration.

“We are very encouraged by the outcome of the follow‐up analysis as it is clear from the results that Xepol brings relief from pain and muscle weakness to PPS patients,” said Johan Häggblad, Managing Director of Pharmalink.
“We are very excited about this data as currently there is no medical treatment for PPS and patients in the treated group have experienced a reduction in disease symptoms after just 12 months.”

“It is very rewarding to see that Xepol is demonstrating efficacy and the potential to help PPS patients,” said inventor and principal investigator Professor Kristian Borg. “We are looking forward to expanding the Xepol treatment procedure following product registration.”

Pharmalink is actively seeking a partner to bring Xepol® to the market. More than 1000 PPS patients have been treated with the drug and many return on an annual basis for new treatment courses. Xepol® has already achieved Orphan Drug Designation in the US and is patented in the major markets.

  citocinas 2

APPLAC México a la vanguardia en el Síndrome de Post Polio

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