Nov 17, 2010

Important Medicine News Stem Cells Reach New HeightsAnd More..

Stem Cells Reach New Heights

NEW YORK (Ivanhoe Newswire) -- 

What is subjected to more weight and is injured more than any other joint in our body? The answer is our ankles. When an injury, sprain or break doesn't heal right the problem creeps up years later in the form of arthritis. A new procedure using stem cells from the patient's own body is regenerating joints and giving people more mobility.

Vern Tejas spends most of his life on top of the world.
His resume includes conquering Mount McKinley 40 times, Mount Kilimanjaro 20 times and Mount Everest nine times.

"The physical challenge of going someplace that's off the beaten road…" Tejas told Ivanhoe.
A broken ankle from 30 years ago created his biggest barrier yet.
"It's getting to the point where I'm limping," Tejas explained.
The cartilage in between his subtalar joint right below the ankle, was gone.

"The conventional treatment for that is to fuse the subtalar joint which means make it stiff," S. Robert Rozbruch, M.D., chief, Limb Lengthening and Complex Reconstruction Service Hospital for Special Surgery, said.
That's not an option for Tejas. So, doctors tried a new approach. Implant a fixator for three months that pulls apart the joint. Then, inject stem cells in the new four-millimeter space where cartilage will regenerate.
"We used stem cells derived from his pelvis," Dr. Rozbruch added.

Read more

   Osteoarthritis Pain Relief
The most common type of osteoarthritis pain, knee pain, may become less severe, or even eliminated all together with a new type of drug for musculoskeletal pain, a new trial suggests.

The drug, tanezumab, has been placed on hold however, because 16 out of thousands of patients began to experience more severe arthritis after taking the medication. "The bottom line is this is a very effective drug for relieving pain; unfortunately, it appears some people go on to have their osteoarthritis progress more quickly," Thomas Schnitzer, M.D., a rheumatologist and professor in the department of physical medicine and rehabilitation at Northwestern Medicine, was quoted as saying.
Tanezumab is the first drug that has been discovered to treat this type of pain in over 100 years. "It's very exciting to have a new approach to manage pain for osteoarthritis," Dr. Schnitzer said.
"The effects of tanezumab were remarkable," Nancy Lane, M.D., professor of internal medicine at UC Davis School of Medicine, added. "People on the drug went from having very limited activity to practically being on the dance floor. No medication available today has such dramatic results."
The explanation for those 16 patients who are suffering bad side effects? Dr. Schnitzer and Dr. Lane suggest the worsening of their conditions may be because tanezumab increased the patient's activity. As a result, more stress on their diseased joints was the result.
Tanezumab blocks Nerve Growth Factor (NGF). NGF is a molecule needed for the normal development of the human nervous system. NGF is responsible for triggering pain.
"The FDA may decide it's too dangerous overall or, rather, that there may be a specific patient population in which it should not be used or who need to be warned about possible serious side effects," Dr. Schnitzer concluded.
SOURCE: New England Journal of Medicine, September 26, 2010.
Weight Loss: Mind Control
ANN ARBOR, Mich. (Ivanhoe Newswire) -- Can your mind control your health? Researchers at Harvard say 75 percent of all disease could be impacted by a better relationship between the mind and body. So if your mind can make you sick, can it also make you better? From healing faster to controlling pain to losing weight -- some believe we can think ourselves healthy.
John Cressman was 7 years old when he fell into a fire pit.
“I put my hands in to catch myself. I remember looking down at my hands and seeing the skin almost melted," Cressman told Ivanhoe.
Doctors told him he suffered third degree burns, would need skin grafts and could lose feeling in his fingers forever.
“I knew it was bad, and I knew it was painful,” Cressman recalled.
With his hands wrapped, he was sent home. Although he was focused on a fast recovery, he never imagined what he would see three weeks later when the bandages were removed.
“The skin, which I still remember them peeling off, had re-grown," Cressman said. "I know the power of the mind is amazing.”
It’s that power that psychotherapist Peggy Huddleston tries to capture for thousands of people before surgery.
“No one is going to have positive emotions about surgery," Huddleston said. "Everyone has negative emotions, but it’s how you can see it as a positive.”
Huddleston created five steps for patients to use before, during and after surgery. A Harvard study reports the program reduces anxiety and promotes healing. The steps include listening to a relaxation CD twice a day several days before surgery.
Step two: positive healing imagery. That's taking worries and turning them into positive thoughts.
“The third step is my favorite one," Huddleston explained. "They ask their friends and family to think of them wherever they are in the world and to wrap them in a blanket of love.”
Step four: The patient takes healing statements from the book and tapes them to their hospital gowns. The doctor then reads the statements during the surgery.

Gynecological surgeon Nina Carroll has been using the Huddleston technique for several years. Skeptical at first, her patients quickly changed her mind.
“Instead of being in bed, uncomfortable, the frown on the face, distant with the post-operative pain experience, they were like, ‘Hi, Doc, how are you? I’m fine,'" Carroll explained.
The last step to healing faster: meet your anesthesiologist. A Harvard study found that by just meeting your doctor, you’ll be calmer. Another study also shows calmer patients used 50 percent less pain medication and went home 2.7 days earlier than those who didn’t meet their doctor.
“It really seemed like my body was listening to the suggestions that I was imagining in my mind,” patient Debra Burns said.
Debra Burns used the technique before a biopsy.
"During the actual biopsy, I didn’t feel any pain,” Burns recalled.
“When there is expectation of recovery, that expectation changes brain physiology,” Jon-Kar Zubeita, M.D., Ph.D., Professor of Psychiatry and Radiology at the University of Michigan, said.
But some say a quick lesson on the positive will not affect your surgery outcome.
"They imply that all you need is to assume a positive attitude, and everything will be OK," Richard Sloan, Ph.D., Professor of Behavioral Medicine at Columbia University Medical Center, said. "That’s very different from being characteristically optimistic. There’s no evidence you can assume a positive attitude and survive.”
Lisa Bohner hopes that’s not true. She plans to use the power of her mind to not just lose weight-- she’s hoping for much more.
“To live, because right now, I only merely exist," Bohner said. "That’s all that I do.”
She’s traveled from Ireland to Spain for a chance at a new life.
“I’m 455 lbs.," Bohner explained. "I sleep in a hospital bed, and I walk with a roll aider, and I refuse to stay in bed and say ‘I’m done."
Instead, she’s trying a new experimental technique -- Gastric Mind Band. Patients are hypnotized and imagine they are having gastric lap-band surgery.

Patients imagine a band is being placed around the upper part of the stomach, creating a smallerfood pouch -- reducing the size of their stomach from a coconut to a golf ball.

“It works if people want it to work," Marion Shirra, a clinical therapist at Gastric Mind Band in Malaga, Spain, said. "It’s so effective because we’re working on people’s minds.”
Joh Smith underwent mind band two years ago.
“When I came back, I knew that I hadn’t had an operation, but then when I went to go and eat, something had changed," Smith recalled. "All I know now is I can’t physically eat the same amount of food I used to eat.”
Joh was 184 pounds and had given up on diets. She’s now 50 pounds lighter and hopes to be an inspiration for Lisa and others like her.
“I’m going to do everything I can to make it work, follow what they want me to do and keep my fingers crossed,” Bohner said.
Expectation is a big part of mind over medicine. A Duke study looked at its role in pain relief. When scientists gave volunteers identical dummy pills before and after an electric shock, they told some the pills cost two dollars and 50 cents -- others only 10 cents. Eighty-five percent of those getting the more expensive pill reported relief compared to 60 percent of the people who got the less expensive version.

APPLAC México a la vanguardia en el Síndrome de Post Polio

Nov 15, 2010





  Liliana Marasco Garrido, President and Co-Founder of Litaff
         Shari Fiksdal, President & Co-Founder of International
                                                          Post Polio Support 

Three important issues came from the symposium, we feel it is important that we share this latest news with everyone.
Some may already know there is a WHO Code for Post Polio Syndrome, that there is
a possible marker waiting for approval by the ...Journal 
 And that they are continuing to find IV Gamma globulin is helping those
of us with PPS!  We apologize that this release has been delayed due to to ill health.




Dr. Brian Joseph, PhD. (Harvard) brought us up to date on IV Gamma Globulin Studies of
Dr. H. Gonzalez! Dr. Kristian Borg and Henrick Gonzalez in Sweden have been working for
many years testing the benefits of IV Gamma Globulin for PPS patients. 
Dr. Joseph asked Dr. Henrik Gonzalez about their test results since their last release in 2008. 
Dr. Joseph explained that the tests being done in Sweden by
Dr. Henrick Gonzalez and Dr.  Kristian Borg had proven to be successful
and their research into the cause of PPS was “revolutionary

1.   The study proved gamma helps PPS.
2.  The study shows we have fragments of polio protein in our spinal cords, which causes our immune systems to continue to battle the polio virus that was there.  This and not dying neurons is what is causing PPS by weakening our immune systems.  Our body is still in the fight mode to kill off the tiny polio fragments in our bodies.  This does not mean we still have polio,  just remnants of the old virus our immune systems are still attacking, causing further degeneration.
 3.  And even more importantly, they have found a blood test to tell if you have PPS!                                                                                                                                  
Dr. Brian Joseph 
The details will all be released as soon as the peer review process is complete.

Here is a letter from Dr. Henrik Gonzalez to Liliana Marasco Garrido of Litaff confirming the statements above!
From: Henrik Gonzalez
Date: 5 de agosto de 2010 14:34:29 CDT
 To: "Asociacion Postpolio Litaff A.C_ APPLAC" <>
 RE: Re: Dr. Henrik Gonzales Regards From México PPS Organization
 Very nice to hear from You Liliana.
 Brian and I have corresponded for some years.  For your information, we have two unpublished studies.

When studies are unpublished I am not able to tell you too much about the results, but:

 The first is the one year follow up of Xepol (IVIG) with very promising results and the other
 a method to diagnose PPS by a very simple blood test.
  Very warm regards
 You can read below that Grifols has already bought the rights to Xepol:                             

Mtra. RitaVelásquez Lerma,
Subdirectora de Registros de Salud y Discapacidad Del INEGI

Sin título1ppp-copia-1

World Health Code  for  PPS “G 14” for PPS:          

In 2009 and as a result of the annual meeting of the Committee on
Review and Update of the World Health Organization (WHO), which
took place in the Indian capital Delhi during the month of October 2008,
the International Classification Diseases, version 10 (ICD-10) has been awarded
specific location to Post-Polio Syndrome (PPS) classified under
the code "G14" and excluded from code B91 (Sequelae of poliomyelitis), which
considered it before this body covered. International Statistical Classification of
Diseases and Related Health Problems. "With these changes the codes are assigned by
the WHO as one can read:"

Classification of polio sequelae and late effects and secondary

(ICD-10, WHO) .                                 
                                                         G14 Postpolio 
                  Includes:  Post Polio  Syndrome   -  Excludes: Postpolio Sequelae

  Dr. Susanna Reyes Rodriguez presented the latest information on

Transfer Factor and IV Gamma studies in Mexico!


Dra. Rodriguez is already using Transfer Factor in Mexico and had just finished
her studies with PPS and IV gamma. 
Dra. Rodriguez said she had found gamma to be helpful in other
Central Nervous System illnesses
and was looking forward to furthering her studies with PPS. 
 She had one medical institution and  Dr. Carlos Vallbona  volunteer to help her work with these studies.
                                                      Warm regards to all,
        Sin títuloliliana             shai       
   Mrs.  Liliana Marasco Garrido                             Shari Fiksdal, President ; Co-Founder  
    Post Polio Association Litaff ,A.C_APPLAC                                         International Post Polio Support Org. 
          Sin título19                                                                               Sin título18
                                                        Mr. Ernesto Maury Ruiz
                                                    Vice President & Cofounder
Websites:  APPLAC  or
Email       APPLAC  
                 Tel/Fax  : Litaff (52) 55742926     IPPSO  (01) 541-772-1102
 © ® To republishedthis this press release you must get permission from
Liliana  Marasco Garrido or Shari Fiksdal and it must be republished in
it's entirety if permission is received.
Prohibida su publicación, todos los derechos reservados, solicitar
permiso a Liliana Marasco Garrido Presidenta y Fundadora de
APPLAC o a Mrs Shari Fiksdal ©®
      STOCKHOLM, SWEDEN – 26 August, 2008 ‐
 Pharmalink AB today announces positive results from a follow‐on Phase III study of Xepol®,
its candidate for the treatment of post‐polio syndrome (PPS). The data have shown the candidate to be effective an
d well tolerated with no serious adverse events attributed to the product being reported in the treated patients.
The Phase III study, involving 142 patients, is a placebo controlled, double blind trial designed to evaluate the efficacy
and safety of Xepol® in PPS, a neurological pain and weakness syndrome in patients that have survived poliovirus infection.
The original placebo controlled, double blind Phase III trial was six months
(Gonzalez et al (2006) Lancet Neurology 5:493‐500)
and this follow‐ up period was another six months.
The follow‐on results strengthen the position of this novel treatment modality for PPS by demonstrating a reduction of
inflammatory  cytokines in the cerebrospinal fluid and a significant reduction of symptoms of PPS while also showing that Xepol®
is safe and well tolerated with few or no side‐effects. Endpoints studied were pain, walking ability and SF‐36 scores (a common self assessment scoring system that measures physical and psychological variables).
 All showed significant and clinically meaning fulresults. Full results are to be published in a peer review journal.
Xepol®, the first medical PPS treatment , is an injectable biologic product, administered once per 9‐12 months, which down
‐regulates the inflammatory process in the nervous system of PPS patients. The concept and medical hypothesis was first developed by Dr Henrik Gonzalez and Professor Kristian Borg, scientists at the Karolinska Institute (Sweden)
. Pharmalink licensed the invention and is now working to bring the candidate towards registration.

“We are very encouraged by the outcome of the follow‐up analysis as it is clear from the results that Xepol brings relief from pain and muscle weakness to PPS patients,” said Johan Häggblad, Managing Director of Pharmalink.
“We are very excited about this data as currently there is no medical treatment for PPS and patients in the treated group have experienced a reduction in disease symptoms after just 12 months.”

“It is very rewarding to see that Xepol is demonstrating efficacy and the potential to help PPS patients,” said inventor and principal investigator Professor Kristian Borg. “We are looking forward to expanding the Xepol treatment procedure following product registration.”

Pharmalink is actively seeking a partner to bring Xepol® to the market. More than 1000 PPS patients have been treated with the drug and many return on an annual basis for new treatment courses. Xepol® has already achieved Orphan Drug Designation in the US and is patented in the major markets.

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APPLAC México a la vanguardia en el Síndrome de Post Polio

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