Jul 20, 2012

Lastes News of Pakistan,WHO,Polio Vaccination



Shakil Afridi had no role in Pak polio campaign: WHO

Amin Ahmed 
Dawn
Publication Date : 20-07-2012

The World Health Organisation (WHO) yesterday said that Dr Shakil Afridi was never part of any genuine or fake polio vaccination programme in Pakistan and noted that baseless reports linking him to anti-polio efforts had served to damage the ongoing immunisation campaign in the country.
The WHO said it was wrongly claimed that Dr Afridi had used polio vaccine to track down al-Qaeda chief Osama bin Laden in Abbottabad.
“It has been claimed, in fact, that Dr Afridi was inoculating hepatitis vaccine with syringes and was collecting blood samples in the neighbourhood for genetic investigations,” the WHO said.
“The misinformation has unfortunately raised doubts on real objectives of the polio eradication campaigns, hampering the efforts of dedicated polio staff.”
The WHO clarified that not only Dr Afridi was not part of the polio eradication programme but also that polio vaccine was administrated with only two drops in the mouth of children below five years of age and, therefore, did not allow collection of blood samples.
The government health departments along with the WHO, Unicef and Rotary International were trying their level best to clear the misconceptions and make people understand that polio vaccination was crucial for their children’s wellbeing, it said.
“The situation is now gradually improving with the help of religious leaders and clerics who are playing an instrumental role in clearing misconceptions about the polio vaccine and its impact on children’s health.”

Jul 17, 2012

Intravenous immunoglobulin treatment of the post-polio syndrome: sustained effects on quality of life variables and cytokine expression after one year follow up.


 2012 Jul 9;9(1):167. [Epub ahead of print]

Intravenous immunoglobulin treatment of the post-polio syndrome: sustained effects on quality of life variables and cytokine expression after one year follow up.

Abstract

ABSTRACT:

BACKGROUND:

Expression of inflammatory cytokines in cerebrospinal fluid (CSF) has led to the hypothesis of intrathecal chronic inflammation to explain the denervation observed in post-polio syndrome (PPS). It has been shown that therapy with intravenous immunoglobulin (IVIG) improves physical performance and dampens down the inflammatory process at 6 months in PPS patients. We here examined the effects of IVIG on cytokine expression and clinical outcome one year after IVIG treatment.

METHODS:

From a previous study with 135 PPS patients included, 41 patients were further evaluated before un-blinding for one year (21 placebo and 20 treated with IVIG, Xepol(R) 50 mg/ml), and were assessed for clinical variables by performing the Short Form-36 survey (SF-36) questionnaire assessment, the 6 minute walk distance test (6MWT) and registering pain level by Visual Analogue Scale (VAS) after IVIG treatment. A separate cohort of 37 PPS patients went through lumbar puncture (LP) at baseline and 20 patients, treated with IVIG, repeated the LP one year later. Thirty patients affected with other neurological diseases (OND) were used as control group. Inflammatory cytokines TNF, TGFbeta, IFNgamma, IL-23, IL-13 and IL-10 were measured in blood cells and CSF cells with RT-PCR.

RESULTS:

Scores of the physical components of SF-36 were significantly higher at the one year follow up time-point in the IVIG-treated patients when compared to baseline as well as to the control subjects . Pain VAS score and 6MWT improved significantly in the IVIG-treated patients when compared with baseline Relative expression of TNF and IFN-gamma in both PBMCs and CSF from PPS patients were increased compared to OND subjects at baseline (p<0.05). One year after IVIG-treatment a decreased expression of IFN-gamma and IL23 was found in CSF of PPS patients, while anti-inflammatory IL-13 was increased (p<0.05).

CONCLUSIONS:

IVIG has effects on relevant QoL variables and inflammatory cytokines up to one year in patients with PPS. This gives a basis for scheduling IVIG in upcoming trials with this therapy.
Gonzalez HKhademi MAndersson MPiehl FWallström EBorg KOlsson T.

Source

Department of Neuroimmunology Unit, Center for Molecular Medicine, Karolinska Hospital, Stockholm, Sweden.
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