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Sep 18, 2013
a) “Road map” representations (36, 37) of poliovirus (Left) and rhinovirus-14 [Right; (33)]. The corresponding triangular area of the capsid surface, bounded by a 5-fold and two 3-fold icosahedral symmetry axes, is marked (Inset). The radial distances of surface residues from the virion center are color coded and contoured [see key (Top Right)]. Nomenclature: 3145, residue 145 of VP3. The receptor footprints are shown in white. (b) A ribbon diagram (38) of the sPvr model is flanked by two views (39) of a single sPvr molecule as portrayed in the cryoelectron microscopy density map (white cage), enclosing the model of the three sPvr domains, d1 (cyan), d2 (orange), and d3 (violet). Carbohydrates attached to d2 [to N188(Left) and N237 (Right)] and possibly to d1 are shown in brown. Also shown are the capsid proteins VP1 (blue), VP2 (yellow), VP3 (red), and VP4 (green). The tunnel beneath the sPvr-binding site is evident (white arrows). “Pocket factor” is magenta. (c) The sPvr sequence is mapped onto secondary structural elements of the homology model. Asn residues thought to be glycosylated are marked with asterisks. (d) Ribbon diagram (38) showing the docking of the sPvr model onto the capsid surface. Same color conventions as in b. The axes allow this view to be related to Fig.. (e) Schematic diagram showing a possible binding configuration of poliovirus with intact membrane-bound Pvr.http://www.pnas.org/content/97/1/73.long
More than 400 eminent scientists from 80 countries around the world have announced their backing for an ambitious global plan to eradicate polio, a disease that once paralysed and killed millions.
Despite security threats and doubts about funding, scientists say the aim of ending polio so that “no child will ever again be crippled by this disease” is achievable.
Launching the Scientific Declaration on Polio Eradication, they called on governments, international organisations and philanthropic individuals to fund the $5.5bn (£3.5bn) cost of eliminating the few remaining cases of polio and end transmission of the disease by 2014, so that the world may be declared polio-free in 2018.
The goal is remarkably close. After a quarter century of eradication efforts the number of cases has fallen more than 99 per cent – from 350,000 in 1988 to 223 in 2012. So far this year – up to 9 April – there have been 18 cases.
There are just three countries remaining where the disease is still endemic – Afghanistan, Pakistan and Nigeria – compared with 125 in 1988.
But there remain huge barriers. The global eradication effort has already missed four deadlines for elimination of the disease – often because funds fell short and polio resurged.
At a briefing in London, experts said 90 per cent of the funding for the first year of the programme was already in place, but a further $2bn was required in later years.
“We need to get the money upfront so that the programme can run unhampered,” said Jay Wenger, director at the Gates Foundation.
In the mid-2000s, an outbreak of polio in Nigeria spread across West Africa, re-infecting countries that had previously eliminated the disease. “That cost half a billion dollars to put right,” Dr Wenger said.
The other major threat to the success of the programme is security: 23 clinic workers were shot dead in Pakistan and Nigeria between December and January by terrorists who believed the vaccination programme was part of an American plot. David Heymann, chair of Public Health England, said: “Eliminating the last 1 per cent of cases is an immense challenge. But by working together we can make history.”
Post Polio Litaff, Association A.C _APPLAC Mexico
Sep 17, 2013
Guest contributor- Olivia DePaulis
Polio, postpolio, vacunas, erradicación, Eli Lilly and Co, Franklin D. Roosevelt, The National Foundation for Infantile Paralysis NFIP Salk’s vaccine
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