Nov 10, 2015

It’s Been 1 Year Since Africa Has Had Any New Polio Cases

Tuesday marks one year since Africa has had any new polio cases, a monumental step toward the continent being completely rid of the disease.
Since a case was recorded in Somalia a year ago, there has been no evidence of any new incidents, an accomplishment advocates attribute to a collaborative, multi-tiered effort, UNICEF noted. Volunteers, religious leaders, health workers and government agencies have banded together to bring vaccines to rural areas and to dispel myths associated with getting the shots.
<span class='image-component__caption' itemprop="caption">A Somali baby is given a polio vaccination before being given a pentavalent vaccine injection at a medical clinic in Mogadishu on April 24, 2013. </span>CARL DE SOUZA/ GETTY IMAGESA Somali baby is given a polio vaccination before being given a pentavalent vaccine injection at a medical clinic in Mogadishu on April 24, 2013. 
Polio mainly affects children under 5 years and can lead to irreversible paralysis and death in some cases when breathing becomes compromised, according to the World Health Organization.
The disease has never been stopped in Afghanistan, Pakistan or Nigeria, according to NPR.
While Somalia has had its hopeful moments over the years, the disease hasn’t yet been completely wiped out.
After three polio-free years, the disease resurfaced in 2005 in Somalia with 185 confirmed cases, and smaller outbreaks the following three years, according to UNICEF.
In 2008 there was an outbreak in Jonglei State, close to the border with Ethiopia.
“It is hard to describe the isolation of this place — an area of marshes, vast cotton-soil plains that become impassable after rains, and an area that has long been plagued by insecurity,” Peter Crowley, head of UNICEF’s polio unit, wrote in a blog post.
Yet, despite such challenges, the outbreak was contained and the area has not experienced a new case since.
<span class='image-component__caption' itemprop="caption">An Ethiopian Somali boy with polio receives medical treatment at a health post in Bisle in the drought-stricken remote Somali region of Eastern Ethiopia.</span>LUC VAN KEMENADE/ASSOCIATED PRESSAn Ethiopian Somali boy with polio receives medical treatment at a health post in Bisle in the drought-stricken remote Somali region of Eastern Ethiopia.
To effectively protect Somalians from the disease, advocates have looked to religious leaders to urge their congregants to get vaccinated.
Some parents resisted getting their children vaccinated, saying that it conflicted with their religious beliefs.
But in 2007, the country saw a major breakthrough when 40 religious leaders from North East Somalia declared their support for polio prevention efforts.
“We agree with the conclusions of the doctors,” Hagi Ali Ahmed, a sheikh from Puntland, said in a statement. “Rumors were wrong. Religious leaders must create awareness in all mosques and among the community.”
Nigeria is also on its way to becoming polio-free.
July marked a year since the country had recorded any new polio cases, NPR reported.
There, health workers also contended with deleterious pushback.
Vaccinators were periodically attacked and killed because religious leaders believed their work to be part of a Western plot to sterilize Muslim children.
<span class='image-component__caption' itemprop="caption">Children wait to receive polio vaccine in Kawo Kano, Nigeria.</span>SUNDAY ALAMBA/ASSOCIATED PRESSChildren wait to receive polio vaccine in Kawo Kano, Nigeria.
While health workers have made extraordinary gains in assuaging suspicions in Nigeria and Somalia, religious leaders have recently grown wary of vaccine campaigns in Kenya.
The country’s Conference of Catholic Bishops recently boycotted WHO’s polio vaccine campaign until it can verify that there is no presence of estrogen in the shots, NPR reported. Dr. Wahome Ngare of the Kenyan Catholic Doctor’s Association accused the organization of introducing female hormone that could sterilize children.
Though health workers and advocates are celebrating Somalia’s latest polio milestone, they’re not at ease just yet.
It will take another two years before the country can officially declare itself polio-free.
“While today’s milestone is extraordinary, it is not an endpoint,” Crowley said. “Nigeria and the many other African countries that remain at risk for polio must maintain high-quality surveillance, work ever-harder to improve the quality of vaccination campaigns and act decisively, should further outbreaks occur.”

Post Polio Litaff, Association A.C _APPLAC Mexico

Nov 9, 2015

Polio May Be Eradicated by 2018

In just three years, the scourge of polio may be gone forever from our planet.
Phil Plait writes Slate’s Bad Astronomy blog and is an astronomer, public speaker, science evangelizer, and author of Death From the Skies!  
This is incredible news. Polio, or more officially poliomyelitis, is a horrible virus that paralyzes 1 in 200 people infected, and kills 5–10 percent of them when it immobilizes the muscles needed to breathe. Put more simply, the virus causes these victims to slowly suffocate.
Mind you, the vast majority of victims are younger than 5.
Polio has been around for centuries at least, but the advent of world travel spread it across the globe. In the U.S., there were 20,000 reported cases of permanent paralysis due to polio in 1952 alone. A vaccine was introduced in 1955 (and an oral version in 1961). What happened next is a triumph of medical science: By 1965 there were fewer than 100 cases in the U.S., and by 1973, fewer than 10.
The U.S. was declared polio-free in 1994.
Numbers globally have dropped precipitously as well, from 350,000 cases in 1988 down to just a few hundred today. The only two countries that have polio in the wild currently are Afghanistan and Pakistan (down from 125 countries in 1988); Nigeria had cases in 2014, but there have been none in 2015.
Polio is transmitted primarily through oral-fecal contact and to a lesser extent through contaminated water; once someone is infected, there is no way to stop the virus.
So then how did polio’s numbers drop so dramatically? Exactly how’d you think: vaccines.
To be more specific, a globally focused and well-organized campaign to vaccinate children around the planet called the Global Polio Eradication Initiative. This wonderful project started in 1988 as a collaboration between multiple nations, and its goal is simple: “To banish polio to the history books.” And they’ve been extremely effective.
Because of the aggressive campaign, it’s expected that the last cases of polio seen in the wild will happen sometime in the next two to three years. The World Health Organization is so confident about this that it actually has what’s called the Polio Eradication and Endgame Strategic Plan, a strategy on how to make the world polio-free by 2018.
That’s extraordinary. This has only happened once before in history, when smallpox was eliminated in 1977. Smallpox killed hundreds of millions of people, and now it’s gone, wiped clean off the face of the planet.
Why? Again: vaccines.
This is why I consider vaccines to be one of the very best medical health innovations in human history, if not the best.
Of course, there are people who think vaccines are unmitigated evil, themselves the cause of diseases and neurological disorders. These anti-vaxxers are gravely mistaken; we know for sure vaccines don’t cause autism and are a huge medical success story. I wonder how many of these folks have looked a polio victim (or someone who was blinded by measles, or grieving parents who just lost an infant to pertussis) in the eye and told them how dangerous they think vaccines are*.

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Of course, some repellent people have. But I hope, like the diseases themselves, their numbers are on the decline.
I was born when polio was waning, but my older brother has told me he remembers seeing newspaper articles with pictures of hospitals showing rows of iron lungs: huge metal canisters that helped polio victims breathe. If you’re younger than me, it’s entirely possible you’ve never seen such a thing, or even heard of them.
That, to me, is a wondrous thing, and one for which I am truly grateful.
Smallpox: gone. Polio: almost gone. When that last case comes, we can finally say goodbye, and good damn riddance.
What’s next? Pertussis, measles, diphtheria, rubella? Those germs better watch their backs, because we’re coming after them, too. And we’ve got science on our side.
Tip of the hat to mactavish on Twitter via DoctorAtlantis.
*In the interest of fairness, I’ll note that the oral polio vaccines contains a weakened virus, which can then be excreted and contaminate water supplies. In some cases this can actually help spread immunity, but if the virus is given enough time it can mutate and become dangerous again. This has happened a couple of dozen times in the past few decades(poor sanitation conditions make this worse, of course), causing about 760 cases of polio, which is awful … but that’s compared with 10 billion doses given, and an estimated 13 million lives saved. Vaccine risks are extremely low compared with their benefit.
 It has been brought to my attention that the Rotary Club has played a crucial role in this as well.

Nov 8, 2015

Rotary honours 90 Polio heroes

Ninety field workers helping to vaccinate millions of children across Nigeria were honored by Rotary International to commemorate a record 16 months without any new case of wild poliovirus.

The 90 Polio Heroes, as they have been named, include vaccinators, supervisors, data analysts, religious leaders and community volunteers who have helped to  "pave the way to the zero-case status," said Rotary's Nigeria National Polio Plus Committee.
The committee's chairman Dr Tunji Funsho said, "We are also remembering profoundly the sacrifices made by the Polio Heroes, especially the nine young women in Kano and three in Borno states that were targeted and killed by gunmen in separate incidents in 2012 and 2013 while working on Polio vaccination campaigns and many others who were kidnapped while trying to vaccinate children in northern states."
"We want to recognise and thank our foot soldiers in the small communities, in our villages," said Funsho. “We also want to motivate them to continue working as they have helped us to reach the milestone we have just crossed."

"They are the reason why we are able to celebrate a Nigeria that has no polio," he added.
The 90 award recipients come from Borno, Kano, Kaduna, Katsina, Sokoto and Zamfara, where surveillance has heightened to track immunized children, monitor environmental samples of the virus and sustain ongoing immunization of children to ensure the disease is eradicated by 2017. 

Rotary, which advocates and raises funds for polio eradication, has contributed over $1.4 billion in philanthropic spending for Polio immunisation in the past 26 years. 
Wide vaccination has helped reduce the presence of polio to Pakistan and Afghanistan, down from 125 countries in 1988, with Nigeria expected to be free of the virus soon. 
Polio Heroes working at local government levels helped Rotarians reach local political leaders to advocate more spending for polio eradication. 
No local government area has reported a case of type 1 wild poliovirus this year, compared with five areas before the last case wa recorded in July last year. 
Type 2 of the virus has not been recorded in the last 18 years and the last record of type 3 was 35 months ago. 
Post Polio Litaff, Association A.C _APPLAC Mexico

Oct 27, 2015

Humanitarian diplomacy offers the olive branch needed in today's violent world

Syrian children who arrive at a refugee camp in Iraq are given polio and measles vaccinations. In war zones and areas of humanitarian crisis, creative negotiations have facilitated crucial vaccination campaigns to reach vulnerable civilians. Photo by: Caroline Gluck / ECHO / CC BY-NC-ND
Our world has become more violent. Trends show that more countries are involved in conflicts and last year 180,000 people were killed in internal conflicts, a number 3.5 times higher than in 2010. The latest Office of the United Nations High Commissioner for Refugees statistics estimate that almost 60 million people are now either refugees or internally displaced because of conflict and violence, the highest number since the end of World War II.
In this context, the achievement of the ambitious new Sustainable Development Goals becomes even more important. Despite the many challenges, the pursuit of these goals is possible and provides crucial opportunities for peaceful conflict resolution.
Humanitarian diplomacy — which advocates on behalf of the needs of vulnerable populations, while upholding humanitarian principles — can open small windows of opportunity that can lead to peace, and at the very least dramatically improve the situation. 
Even in the bloodiest conflicts, when there seems no end in sight, creative negotiations have facilitated crucial vaccination campaigns and interventions to reach desperate civilians. This diplomacy takes place not just at a governmental level, but also through grass-roots advocates who engage community and religious leaders to create a dialogue and enable health professionals to do their work.
From Sri Lanka to Syria and Nigeria, this quiet diplomacy — as practiced by members of the Global Polio Eradication Initiative and its partners, which has reduced polio cases by 99.9 percent since its launch in 1988 —  is creating new models and tactics for humanitarian organizations.
The best practices of humanitarian diplomacy aim to achieve sustainable results by combining top-level negotiations with local peace initiatives. This is in stark contrast to the failing efforts in Syria. Although a report on peace initiatives there concluded that the April 2012 cease-fire brokered by Kofi Annan and other top-level attempts to negotiate cease-fires had “significant humanitarian impact,” the positive impact was short-lived. This is because local actors were not integrated successfully as part of the process.
So how do we actually combine high-level efforts with local initiatives to achieve sustainable humanitarian impact? Here are three principles:
1. Diplomacy is increasingly multilateral: involve as many players as possible.
During the Sri Lankan civil war, the government had originally planned to hold a polio National Immunization Day only in those areas that were not impacted by the war, with the result that only two-thirds of the country’s children would be vaccinated. However, after consultations between Rotary and United Nations Children’s Fund, the two organizations reached out to the rebel army and convinced its leader to agree to an immunization campaign and a cease-fire if the government would also stop the war for two days.
The parties came to an agreement and the subsequent immunization efforts reached approximately 95 percent of the country. By involving all of the relevant parties and utilizing the unique contributions of a nongovernmental organization such as Rotary (rather than just pursuing unilateral action by the government), immunization efforts were converted into an instrument of peace and negotiation.
This tactic — what became known as “days of tranquility” — was successfully used in other countries and demonstrated how creative diplomatic strategies can aid conflict resolution. 
One example saw Rotary work with its partners in the GPEI, as well as the International Committee of the Red Cross and the Catholic Church, to negotiate in El Salvador during the civil war. Allowing health workers to access isolated populations to carry out immunization efforts and the resulting lull in hostilities opened the door for mediators to initiate a dialogue between the warring parties that ultimately led to a lasting peace.
What is the Global Polio Eradication Initiative?
A successful model of cooperation between the public and private sectors, the GPEI is supported by national governments. The core partners are Rotary, the World Health Organization, the U.S. Centers for Disease Control and Prevention, and the United Nations Children’s Fund, joined more recently by the Bill & Melinda Gates Foundation. Today, Pakistan and Afghanistan are the last remaining polio-endemic countries.
But creating these opportunities depends on a strong and local grassroots presence, engaging with as many willing public and private partners as possible, and enlisting the support of internal social and institutional authorities. In this way, localized humanitarian diplomacy that integrates the resources of national and international players not only benefits public health, but complements the efforts of high-level negotiations when progress appears stagnant.
2. Use the strengths of neutrality, independence and principled action.
The importance of neutrality has long been a staple for NGOs and aid organizations, especially when operating in conflict areas or responding to natural disasters. However, the demands of humanitarian diplomacy in the field place ever-increasing pressures on these principles. 
To maintain credibility in a politicized environment, it is important to build trust and ensure local involvement. This can be time-consuming, but becomes crucial whenever tensions arise. For example, the recruitment and induction process for Lebanese Red Cross volunteers can take 9–12 months. This may seem lengthy, but a rigorous selection process to recruit and train professional, impartial, local members of international NGOs operating in volatile areas, ensures that they will be able to act more effectively with the support of the local population.  
Upholding independence is fundamental in peace as well as wartime, as the GPEI learned when embarking on delicate negotiations to reach populations where rejection of vaccines was at high levels. It was only by gaining the support of social and religious leaders that these barriers were overcome, leading to successful and sustainable vaccination efforts.
However, once trust and credibility as nonpartisan, principled actors is lost, it can be very hard to regain. The damaging revelations of ongoing sexual abuse perpetrated by U.N. peacekeepers in the Central African Republic, Liberia, Haiti and elsewhere “can destroy … in a flash” any hard-earned gains of a humanitarian mission, according to Jack Christofides, head of U.N. peacekeeping in Central Africa.
3. Maximize humanitarian opportunities by providing multiple interventions and services.
Using health as a bridge for peace in Sri Lanka and other countries not only created important informal channels of communication across political and ethnic divides, but it facilitated other vital interventions for vulnerable populations. These included the provision of vitamin A tablets, deworming treatments, the distribution of malaria nets and the provision of electricity. 
What this means is that NGOs must be ready to capitalize on opportunities once humanitarian diplomacy creates windows for action.
In summary, whether development professionals target the Syrian conflict and refugee crisis, disease prevention in the developing world, or gender equality, the coalition-building and agile engagement strategies of humanitarian diplomacy will be crucial in achieving many of the benchmarks of the Sustainable Development Goals.
Ending a Global Disease is a conversation hosted by Devex, in partnership with Rotary International, to explore successes in the fight against polio and identify lessons that can be applied to overcoming other global diseases. Visit the campaign site and join the conversation using #endpolio.

Post Polio Litaff, Association A.C _APPLAC Mexico

Oct 13, 2015

5 Cases of Polio in Amish Group Raise New Fears

LONG PRAIRIE, Minn. - Polio was pronounced dead in the Western Hemisphere years ago, after one of the most successful public health campaigns in history. But now it is stealing through a tiny Amish community here in central Minnesota, spreading from an 8-month-old girl to four children on two neighboring farms.
So far, no one has been crippled by the disease; only 1 in 200 cases of polio results in paralysis. But worried public health officials say it may be only a matter of time.
The story of how polio came to this dairy farming community of 24 families, with 19th-century ways that include a deep-rooted suspicion of vaccination, is both a medical whodunit and a cautionary tale, suggesting that eradicating polio may prove far harder than anyone thought, even in the developed world.
No one expects that the United States will be visited by the kind of outbreaks that recently flared up in Africa and Asia, frustrating the longstanding goal of eliminating polio for good by the end of this year. But the Long Prairie cases highlight a weakness in the worldwide campaign.
The 8-month-old Amish girl, whose name has been withheld by health officials, has an immune deficiency that makes her unable to rid her body of the virus.
How she contracted the virus remains a mystery. She may have been infected in a hospital by another immune-deficient patient who nursed it for years. A doctor or nurse may have served as a go-between. Or there may have been a chain of carriers in the Amish community. The virus is spread from stool to mouth, a surprisingly efficient form of transmission.
Regardless, the girl is now a wellspring for polio, a modern-day Typhoid Mary who can pass it along to others. Anyone who has not been vaccinated is vulnerable. And though vaccination rates in the United States are at historic highs, an increasing number of parents are resisting inoculations for their children, fearing that they may cause disorders like autism, a connection scientists have almost universally discounted.
So health authorities are keeping a watchful eye on the girl and her neighbors.
"If that child is a message in a bottle," said Bruce Aylward, coordinator of the global polio eradication initiative at the World Health Organization, "it has just washed up on shore."
The 24 families moved to this windswept stretch of prairie from Wisconsin about three years ago. An Amish community generally includes only as many families as can fit into one house for church services, and each community must come to a consensus on what to accept from modernity.
This one allows windshields for its horse buggies, kitchen cupboards that are attached to walls and some upholstered furniture -- all somewhat unusual for the Amish, said Dr. Susan Rutten, a physician from nearby Sauk Centre who makes house calls in four Amish communities. Men can wear dark green shirts, not just navy blue and black.
The farms could have come straight out of children's books. There are ducks and chickens, cattle and hogs. Fence posts are columns of stones enclosed by wire mesh. Lacking electricity, the farms are remarkably quiet. At one, the children rarely yelled or even spoke in the presence of a stranger. The air smelled of turned earth, manure and wood smoke.
The threat of polio seemed remote here -- until this summer. That was when the baby was hospitalized with an immune-system disorder.
As her care became increasingly complex, she was shuttled through four hospitals. At the third, she developed diarrhea. On Aug. 27, doctors sent a stool sample to the hospital's laboratory, which determined that the girl had an intestinal virus. In many states, nothing more would have been done.
But in Minnesota, hospitals send such samples to a sophisticated state laboratory. On Sept. 29, the tests matured. A laboratory supervisor called Dr. Harry Hull, the state epidemiologist, to say they had isolated a polio virus.
Dr. Hull was stunned. "I said, 'You have made a mistake,' " he recalled.
Tall and thin, with glasses and bushy eyebrows, Dr. Hull is one of the world's foremost polio experts. Before coming to Minnesota, he worked for 10 years in the World Health Organization's global polio eradication effort. In an interview, he scrawled circles and arrows on a sheet of paper as he described the search for the virus.
The state laboratory redid the tests. The results were identical. Then it sequenced the virus's genomic code. A supervisor plugged the code into a national genomic database, comparing it with the genes of a polio virus.
"Bingo," said Dr. Norman Crouch, the laboratory's director. "It was a 98 percent match. We knew we had nailed it."
The Minnesota laboratory sent the sample to the Centers for Disease Control and Prevention in Atlanta, which confirmed the results. Officials were immediately concerned about where the virus originated and where it might have spread.
Confirming the presence of polio in a city with even one infected person is not impossible, said Dr. Mark D. Sobsey, a professor of environmental microbiology at the University of North Carolina. The stool of an infected person contains so many viral particles that tests at a sewage treatment plant can reveal it. Such tests helped track outbreaks in the Gaza Strip and Haiti in recent years.
Since many Amish use outhouses, however, state officials geared up to go door to door. They unearthed a public health form explaining how to collect stool samples. The form had pictures of a flush toilet and a garbage can with a plastic liner -- things foreign to many Amish communities. Officials changed the form.
Gary Wax, an epidemiologist for the Minnesota Department of Health, contacted the leader of the Amish community where the child lives and asked for his permission to seek stool samples from those in his community. The leader gave his blessing, Mr. Wax said.
"We really tried to do it in a respectful way rather than just barge right in there," Mr. Wax said.
Since the Amish have no phones, he could not call for appointments. He and his colleagues knocked on doors. They had been warned against speaking directly to Amish women without their husbands present, Mr. Wax said, and the men were "running all over the place, helping each other with harvesting and construction." So if the man was not at home, they left.
"We came back many times to some places," Mr. Wax said. After weeks of effort, just 5 of 24 families in the community agreed to cooperate. Three of the five, including the family of the 8-month-old, proved to have infected children.
"I would be surprised if we don't get a paralytic case someplace," Dr. Hull said.
In a neighboring community, a 38-year-old farmer who is also a sawyer agreed to speak with a reporter only if his name would not be used, saying Amish people avoided calling attention to themselves.
The farmer, who has seven children, explained that nothing in Amish law forbade vaccinations, but that many Amish believed that vaccines weakened the immune system. He added that as a result of the infections, he planned to have his children vaccinated against polio, measles, mumps and rubella, and that most of the families in his community were doing the same. "We'll get vaccinated if we feel it's necessary," he said. "But our definition of necessary may be very different from yours."
A further challenge for public health officials is that their surveillance efforts cannot be confined to a few remote farming communities.
"My mental image of the Amish was that they don't travel at all because they don't drive cars," Dr. Hull said. "That's not true."
The Amish commonly take buses and trains, and occasionally even planes. Families from the baby girl's community recently attended a wedding in Ontario, Canada, that health officials said drew more than 1,000 guests. Some have visited Wisconsin in recent weeks.
Polio experts have long feared that an immune-deficient person could cause an outbreak of paralytic polio. That is a particular hazard in poorer countries.
In much of the developing world, children are given an oral vaccine made of a live, nonparalytic polio virus. Two drops confer partial immunity, making mass vaccination campaigns achievable in poor countries. To become fully immunized, a child must be vaccinated several times. The vaccine causes an infection that usually lasts a few weeks. The infection can spread to others and immunize them, too.
But if the virus spreads too far among previously unvaccinated people, its genes will change and the virus will regain its ability to cripple and kill. Such a virus caused an outbreak of paralytic polio in Haiti and the Dominican Republic in 2000 and 2001, crippling 21. (The outbreaks in Africa and Asia began after many Nigerians refused vaccinations in 2003, suspecting they were a Western plot to sterilize Muslim girls.)
The United States and much of the developed world used live-virus vaccinations for decades, but switched in recent years to a dead virus that is injected. The dead virus does not cause an infection or paralysis.
In people with poor immune systems like the 8-month-old Amish child, the live polio vaccine can change to a paralytic form without being passed to anyone else, since such people can nurse a mutating virus for years.
In most of the world, such patients die quickly because of poor medical care. In the West, they can live for years, with a few of them shedding polio viruses all the while. Among experts, these patients are called "chronic excreters." That such a polio wellspring would be born among a largely unvaccinated population like the Amish, Dr. Hull said, was a "random unlucky event."
"It's a model of what might happen if we stop vaccinating too soon," he said.
The Amish girl remains hospitalized in strict isolation. Health officials will not say where. And they are still trying to figure out where she contracted the virus.
Genetic testing showed that the virus was almost identical to that of the oral polio vaccine given in much of the rest of the world but not in the United States. The slight changes to the virus from that of the vaccine suggested that it had been circulating for at least two years. The girl has never traveled abroad.
A fear is that such a person could unwittingly incubate a polio infection for a decade or more and then accidentally reintroduce it -- years after experts have declared it eliminated from the world and vaccinations have stopped.
That prospect has long seemed remote, because such children are so rare, Dr. Aylward of the World Health Organization said. But an outbreak of paralytic disease in Minnesota would prove that it was more likely than many had believed, and it would demonstrate that work now under way to better understand the risks posed by chronic excreters would have to be intensified.
"Or we may need to revisit the strategy and time frame for stopping the use of the oral polio vaccine," Dr. Aylward said. “It's a tiny chance, but it's something we need to keep an eye on."

Post Polio Litaff, Association A.C _APPLAC Mexico

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