- The Post-Polio Institute Protein Power "Diet"
- Exercise: Use it and Lose it
- Marijuana for Pain Relief: Study Details
- Fibromyalgia Pain Treatment Options
- Marinos C. Dalakas, MD
- Nutrition and Post-Polio Lauro S. Halstead, MD, National Rehabilitation Hospital, Washington, DC
- Physiotherapy, braces, special shoes, calipers, and in many cases,
- Body's own pain relief 'is best'
- Tips and Techniques for Polio Survivors
- A mutated strain of Polio has made its way to Euro...
- Audio MP3 Aclaración del Código "G14"
- Página principal
Jun 26, 2016
Jun 24, 2016
University of California, Los Angeles (UCLA)
|Susan Perlman, M.D. is Associate Clinical Professor of |
POST-POLIO SYNDROME is a constellation of new symptoms (fatigue, weakness, pain, cold intolerance, muscle atrophy, or new problems with activities of daily living), occurring in survivors of definitively (by history, exam or electrical studies) proven acute poliomyelitis, after a period of at least 15 years of stable recovery and performance, and in the absence of any other medical or neurological condition. It is felt to result from the weakening and loss of previously recovered lower motor neuron connections to muscle, possibly due to aging, greater fragility of the recovered nerves, or immune system dysregulation. Onset can be insidious, progression is usually slow, and treatment is most successful with rehabilitation strategies.Until we better understand the causes of post-polio syndrome, we will have no curative medication. At best, we can use medication to treat the symptoms and to improve the quality of life, and we can avoid using medication that could make the symptoms worse. Certain other diseases (elevated blood cholesterol levels, high blood pressure, heart disease, and cancers) require use of medications with side effects that can exacerbate symptoms of post-polio syndrome. These should be used, but with careful monitoring of the polio survivor's functioning.
- Susan Perlman, MD
The three primary symptoms [of PPS] that we can treat with medication are weakness of muscle, fatigue (individual muscle and generalized) and pain, i.e., post-polio pain, overuse pain, bio-mechanical pain and bone pain ( Gawne, AC, 1995).
Drugs to reverse muscular atrophy or to improve strength by stimulating motor nerve endings to reconnect with muscle fibers (nerve growth factors) are all still experimental. They are currently being tested for use with other motor nerve diseases. Only insulin-like growth factor type 1 (IGF-1), also known as myotrophin or somatomedin-C, has been tested in people with post-polio syndrome (Miller, RG, 1997) (see chart) It brought no change in strength or fatiguability but did improve recovery from fatigue after exercise.
Human Growth hormone has been given to increase a person's natural level of IGF-1 but showed little or no improvement in strength (Gupta, KI, 1994).
Another approach has been to develop and test drugs that would protect the nerve-muscle connection from the new damage in the first place (neuro-protective agents). Again, several have been studied in other diseases, but only selegiline has been tested in post-polio syndrome, bringing some improvement in symptoms but no clear stabilization of the disease (Bamford, CR, 1993). Although many people use over-the-counter antioxidant preparations of various types, these have never been formally tested to prove any ability to slow down the changes of post-polio syndrome.
Anabolic steroids, often used by body builders to improve muscle bulk and power, have been tried by polio survivors and other persons with neuromuscular diseases, but The Medical Letter on Drugs and Therapeutics reports the side effects (risk of prostate cancer in men, masculinization in women) greatly outweigh the potential benefits.
Metabolic stimulants (L-carnitine*, L-acylcarnitine, co-enzyme Q), used to improve the ability of muscle to make energy and possibly reduce fatigue and improve strength, have also been tried by polio survivors, but have been associated with rare allergic reactions and insomnia (Lehmann, C, 1994; Nibbett, J, 1996).
|* A placebo-controlled study, as yet unpublished, recently done in Germany showed no significant difference between placebo and L-carnitine.|
CODIGO G "14" El pasado mes de febrero de 2009 y como resultado de la reunión anual del Comité de Revisión y Actualización de la Organización Mundial de la Salud, (OMS) que tuvo lugar en Delhi, durante el mes de octubre de 2008, la Clasificación Internacional de Enfermedades, en su versión 10 (ICD-10) ha adjudicado un lugar específico al Síndrome Post-Polio (SPP) clasificándolo bajo el código "G14" y excluyéndolo del código B91 (Secuelas de poliomielitis), en el que antes ese organismo lo consideraba abarcado Más informes
Post Polio Litaff, Association A.C _APPLAC Mexico
Polio, postpolio, vacunas, erradicación, decades after the polio, Dr. Salk’s great competitor was Dr. Albert B. Sabin
By: Richard L. Bruno, Published in: American Journal of Physical Medicine a...
Post-polio syndrome [ 13 ] [ 14 ] Importance Respiratory problems in PPS are an important cause of symptoms and complications, i...
Image copyright SCIENCE PHOTO LIBRARY He had an immune disorder that mean the weakened polio virus used to vaccinate him in childhood s...
Dr. Richard Bruno is Chairperson of the International Post-Polio Task Force and ex-Director of The Post-Polio Institute and Int...
If poliovirus were detected in your country, what actions would be taken to prevent its spread? Who would inform the public and coord...
From: Healthy Partnerships. Ontario: March of Dimes, 1995 By: Richard L. Bruno, Ph.D., Nancy M. Frick, Lh.D., Susan J. Creange, M.A., Todd L...
By: Caitlin Beddows , Posted on: August 9, 2016 Dementia is an acquired progressive cognitive impairment leading to interference wit...
1952-1957: Jonas Salk's polio vaccine 1.0k Share Tweet 1952-1957 Dr. Salk's polio vac...
Mumbai, Oct 22 : India is well on its way to eradicate the polio virus, as per the latest World Health Organisation (WHO)da...
THE TEN COMMANDMENTS OF PPS By: Richard Louis Bruno Published in: NEW MOBILITY, June 1999 Dr. Richard L. Bruno, Chairperson International P...
México Post Polio Una Vida Un Camino Una Experiencia
- See more at: http://polioamigossinfronteras.blogspot.mx/#sthash.6PkHAkfM.dpuf
Rincón De Post Polio México-
Polio y Efectos Secundarios SPP
- ► 2019 (86)
- ► 2018 (61)
- ► 2017 (119)
- ► 06/19 (3)
- ► 2015 (46)
- ► 2014 (46)
- ► 2013 (73)
- ► 2012 (84)
- ► 2011 (31)
- ► 2010 (126)